Beyond neurodegenerative diseases: α-synuclein in erythropoiesis. Issue 1 (31st December 2022)

• Record Type: Journal Article
• Authors: Ling, Ling; Wang, Fangfang; Yu, Duonan
• Is Part Of: Hematology. Volume 27:Issue 1(2022)
• Page Start: 629
• Page End: 635
• Publication Date: 2022-12-31
• Subjects: α-synuclein -- GATA1 -- erythropoiesis -- iron homeostasis -- anemia -- hematopoiesis -- erythroid α-syn -- Parkinson's disease; Blood -- Diseases -- Periodicals; Hematology -- Periodicals; Blood -- Transfusion -- Periodicals; 616.15005
• DOI: 10.1080/16078454.2022.2078041
• Languages: English
• ISSNs: 1024-5332

Abstract

ABSTRACT: α-synuclein (α-syn) is a highly conserved and thermostable protein that is widely distributed in human brain. An intracellular aggregation of α-syn in dopaminergic neurons is the hallmark of a group of neurodegenerative diseases including Parkinson's disease. Interestingly, α-syn is also highly expressed in red blood cells and is considered as one of the most abundant proteins in red blood cells. Moreover, α-syn is thought to play a regulatory role during normal erythropoiesis. However, whether α-syn participates in the pathogenesis of erythroid diseases has not been reported. In this review, we discuss the protein structure of α-syn and the importance of α-syn in erythropoiesis.