Prenylated coumarins from the fruits of Artocarpus heterophyllus with their potential anti-inflammatory and anti-HIV activities. Issue 10 (23rd May 2022)

• Record Type: Journal Article
• Authors: Tao, Lei; Zhuo, Ya-Ting; Qiao, Ze-Hua; Li, Juan; Tang, Hao-Xuan; Yu, Qiao-Mei; Liu, Yun-Yao; Liu, Yan-Ping
• Is Part Of: Natural product research. Volume 36:Issue 10(2022)
• Page Start: 2526
• Page End: 2533
• Publication Date: 2022-05-23
• Subjects: Carpus heterophyllus -- prenylated coumarins -- artoheteronin -- anti-inflammatory activities -- anti-HIV-1 activities; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1913590
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A phytochemical investigation on the fruits of Artocarpus heterophyllus led to the isolation and characterisation of a new prenylated coumarin, artoheteronin (1 ), together with six known analogues (2 −7 ). The chemical structure of 1 was elucidated using extensive spectral methods and the known compounds (2 −7 ) were identified by comparing their spectral data with those reported in the literature. All known compounds (2 –7 ) were isolated from the genus Artocarpus for the first time. The anti-inflammatory and anti-HIV activities of all isolated prenylated coumarins (1–7) were assessed in vitro. As a result, compounds 1 –7 displayed notable inhibitory effects against nitric oxide (NO) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro with the IC50 values in range of 0.58 ± 0.06 to 6.29 ± 0.12 μM. Meanwhile, compounds 1 –7 exhibited notable anti-HIV-1 reverse transcriptase (RT) activities possessing EC50 values in the range of 0.18 to 9.12 µM. Graphical Abstract: UF0001