The modulatory effects of irisin on asprosin, leptin, glucose levels and lipid profile in healthy and obese male and female rats. (4th May 2022)

• Record Type: Journal Article
• Authors: Ozcan, Sibel; Ulker, Nazife; Bulmus, Ozgur; Yardimci, Ahmet; Ozcan, Mete; Canpolat, Sinan
• Is Part Of: Archives of physiology and biochemistry. Volume 128:Number 3(2022)
• Page Start: 724
• Page End: 731
• Publication Date: 2022-05-04
• Subjects: Irisin -- asprosin -- leptin -- obesity; Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.1080/13813455.2020.1722706
• Languages: English
• ISSNs: 1381-3455

Abstract

Abstract: Objectives: The main aim of this study was to investigate the effects of irisin on asprosin, leptin, glucose levels and lipid profile in healthy and obese male and female rats. Methods: Irisin was subcutaneously administered with osmotic minipumps at the dose of 100 ng/kg/day for 28 days and then, the serum levels of asprosin, leptin, glucose and lipid profile were investigated. Results: Irisin infusion increased asprosin levels in male rats ( p = .02) but not in female rats. Irisin inhibited obesity-induced high glucose, low-density lipoprotein (LDL), triglyceride (TG) and leptin levels in all groups; however, it did not lead to any change in asprosin levels in both obese female and male rats. Conclusions: It was determined that irisin increased serum asprosin levels and decreased LDL, TG, glucose and leptin levels, and this could indicate a protective role of irisin against obesity development.