Flow technology enabled preparation of C3-heterosubstituted 1-azabicyclo[1.1.0]butanes and azetidines: accessing unexplored chemical space in strained heterocyclic chemistry. Issue 43 (10th May 2022)

• Record Type: Journal Article
• Authors: Musci, Pantaleo; Colella, Marco; Andresini, Michael; Aramini, Andrea; Degennaro, Leonardo; Luisi, Renzo
• Is Part Of: Chemical communications. Volume 58:Issue 43(2022)
• Page Start: 6356
• Page End: 6359
• Publication Date: 2022-05-10
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc01641a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The use of flow technology as an enabling tool for accessing 1-azabicyclo[1.1.0]butanes bearing strained 3-, 4-, and 5-membered O-heterocycles with C3(N-het) –C2(O-het) connectivity is reported. Abstract : The use of flow technology as an enabling tool for accessing 1-azabicyclo[1.1.0]butanes bearing strained 3-, 4-, and 5-membered O-heterocycles with C3(N-het) –C2(O-het) connectivity is reported. Reactivity and chemoselectivity (N-ring vs. O-ring) were also evaluated. New chemical space has been explored and new structural motifs such as ABB-aziridines or spiro azetidine-oxazetidines are also reported.