Cobalt-catalyzed tandem one-pot synthesis of polysubstituted imidazo[1, 5-a]pyridines and imidazo[1, 5-a]isoquinolines. Issue 20 (12th May 2022)

• Record Type: Journal Article
• Authors: Meena, Neha; Dhiman, Shiv; Rangan, Krishnan; Kumar, Anil
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 20(2022)
• Page Start: 4215
• Page End: 4223
• Publication Date: 2022-05-12
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob00526c
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An efficient cobalt-catalyzed tandem one-pot method has been developed for the synthesis of polysubstituted imidazo[1, 5- a ]-N-heteroaromatics. Abstract : An efficient cobalt-catalyzed tandem one-pot method has been developed for the synthesis of polysubstituted imidazo[1, 5- a ]-N-heteroaromatics. The method involves Knoevenagel condensation followed by cobalt-catalyzed direct alkenylation to give the desired polysubstituted imidazo[1, 5- a ]pyridines and imidazo[1, 5- a ]isoquinolines in a one-pot manner. This method exhibits a broad substrate scope, provides moderate to good (39–74%) yields and is amenable to scale-up to the gram scale.