Passerini chemistries for synthesis of polymer pro-drug and polymersome drug delivery nanoparticles. Issue 20 (26th April 2022)

• Record Type: Journal Article
• Authors: Travanut, Alessandra; Monteiro, Patrícia F.; Smith, Sean; Howdle, Steven M.; Grabowska, Anna M.; Kellam, Barrie; Meier, Michael A. R.; Alexander, Cameron
• Is Part Of: Journal of materials chemistry. Volume 10:Issue 20(2022)
• Page Start: 3895
• Page End: 3905
• Publication Date: 2022-04-26
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d2tb00045h
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : New materials chemistries are urgently needed to overcome the limitations of existing biomedical materials in terms of preparation, functionality and versatility, and also in regards to their compatibility with biological environments. Abstract : New materials chemistries are urgently needed to overcome the limitations of existing biomedical materials in terms of preparation, functionality and versatility, and also in regards to their compatibility with biological environments. Here, we show that Passerini reactions are especially suited for the preparation of drug delivery materials, as with relatively few steps, polymers can be synthesized with functionality installed enabling drug conjugation and encapsulation, self-assembly into micellar or vesicular architectures, and with facile attachment triggerable chemistries. The polymers can be made with a variety of building blocks and assemble into nanoparticles, which are rapidly internalized in triple negative breast cancer (TNBC) cells. In addition, the polymers transport drug molecules efficiently through 3D cell cultures, and when designed with chemistries allowing pH-mediated release, exhibit greater efficacy against TNBC cells compared to the parent drug.