Direct access to α, α-chlorofluoro arylketones via mild electrophilic heterohalogenation of arylalkynes. Issue 11 (22nd April 2022)

• Record Type: Journal Article
• Authors: Lin, Chuyuan; Chen, Lu; Lin, Huaping; Li, Yibiao; Shen, Chengshuo; Zhang, Min
• Is Part Of: Organic chemistry frontiers. Volume 9:Issue 11(2022)
• Page Start: 2944
• Page End: 2948
• Publication Date: 2022-04-22
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d2qo00074a
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : By employing a compatible system of selectfluor and NaCl, a new practical approach for direct access to aryl α, α-chlorofluoro arylketones via mild electrophilic heterohalogenation of arylalkynes is presented. Abstract : By employing a compatible system of selectfluor and NaCl, we herein report a new and practical approach for direct access to aryl α, α-chlorofluoro arylketones in aqueous trifluoroethanol via mild electrophilic heterohalogenation of arylalkynes, featuring metal-free conditions, readily available feedstocks, and good functional group tolerance. The present work offers a raw material basis for further preparation of fluorinated organic molecules.