Total and Unbound Doravirine Concentrations and Viral Suppression in CSF. (21st September 2021)

• Record Type: Journal Article
• Authors: Tiraboschi, Juan; Scévola, Sofia; Penchala, Sujan Dilly; Challenger, Elisabeth; Else, Laura; Prieto, Paula; Saumoy, Maria; Imaz, Arkaitz; Silva-Klug, Ana; Niubó, Jordi; Soriano, Irene; Khoo, Saye; Rigo-Bonin, Raul; Podzamczer, Daniel
• Is Part Of: Clinical infectious diseases. Volume 74:Number 10(2022)
• Page Start: 1855
• Page End: 1858
• Publication Date: 2021-09-21
• Subjects: Doravirine -- CNS -- CSF -- concentrations -- unbound -- HIV; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciab835
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: We determined total and unbound concentrations of doravirine (DOR) in cerebrospinal fluid and blood plasma. Total and unbound DOR concentrations in cerebrospinal fluid exceeded the half-maximal effective concentration against wild-type virus (5.1 ng/mL) in all patients, suggesting that DOR may contribute to inhibit viral replication in this compartment.