Evaluation of endometrial receptivity and implantation failure. Issue 3 (June 2022)

• Record Type: Journal Article
• Authors: Bui, Anthony H.; Timmons, Douglas B.; Young, Steven L.
• Is Part Of: Current opinion in obstetrics and gynecology. Volume 34:Issue 3(2022)
• Page Start: 107
• Page End: 113
• Publication Date: 2022-06
• Subjects: endometrial receptivity -- implantation -- molecular profiling; Obstetrics -- Periodicals; Gynecology -- Periodicals; Genital Diseases, Female -- Indexes; Genital Diseases, Female -- Periodicals; Obstetrics -- Indexes; Obstetrics -- Periodicals; Review Literature -- Periodicals; 618.005
• DOI: 10.1097/GCO.0000000000000783
• Languages: English
• ISSNs: 1040-872X

Abstract

Abstract : Purpose of review: To succinctly review the basic mechanisms of implantation and luteal phase endometrial differentiation, the etiologies of impaired endometrial function and receptivity, and the current methods that exist to evaluate and treat impaired endometrial receptivity. Recent findings: Human embryo implantation requires bidirectional communication between blastocyst and a receptive endometrium. Etiologies of impaired endometrial receptivity are varied. Some of these include delayed endometrial maturation, structural abnormalities, inflammation, and progesterone resistance. Current methods to evaluate endometrial receptivity include ultrasonography, hysteroscopy, and endometrial biopsy. Treatments are limited, but include operative hysteroscopy, treatment of endometriosis, and personalized timing of embryo transfer. Summary: Although some mechanisms of impaired endometrial receptivity are well understood, treatment options remain limited. Future efforts should be directed towards developing interventions targeted towards the known mediators of impaired endometrial receptivity.