Oxytocin at Elective Cesarean Delivery: A Dose-finding Study in Women With Obesity. Issue 2 (24th June 2022)

• Record Type: Journal Article
• Authors: Peska, E.; Balki, M.; Maxwell, C.; Ye, X.Y.; Downey, K.; Carvalho, J.C.A.
• Is Part Of: Obstetric anesthesia digest. Volume 42:Issue 2(2022)
• Page Start: 77
• Page End: 78
• Publication Date: 2022-06-24
• Subjects: Obstetric Hemorrhage -- Pharmacology -- Systems-based Practice; Anesthesia in obstetrics -- Periodicals; Anesthesia in obstetrics -- Abstracts -- Periodicals; 617.968205
• DOI: 10.1097/01.aoa.0000827868.48886.13
• Languages: English
• ISSNs: 0275-665X

Abstract

Abstract : ( Anaesthesia . 2021;76:918–923. [Epub November 23, 2020]) Worldwide, postpartum hemorrhage (PPH) continues to be a major cause of maternal mortality. Uterine atony is a leading cause of PPH in high-income countries and is known to be associated with obesity. Oxytocin is administered to achieve acceptable uterine tone following cesarean delivery (CD); however, it is unknown whether higher doses of oxytocin are required to accomplish this in women with obesity. This dose-finding study examined the oxytocin bolus dose required to initiate effective uterine tone in 90% of women with obesity (ED90 ) following CD under regional anesthesia.