Plasma perfluoroalkyl substance exposure and incidence risk of breast cancer: A case-cohort study in the Dongfeng-Tongji cohort. (1st August 2022)

• Record Type: Journal Article
• Authors: Feng, Yue; Bai, Yansen; Lu, Yanjun; Chen, Mengshi; Fu, Ming; Guan, Xin; Cao, Qiang; Yuan, Fangfang; Jie, Jiali; Li, Mengying; Meng, Hua; Wang, Chenming; Hong, Shiru; Zhou, Yuhan; Zhang, Xiaomin; He, Meian; Guo, Huan
• Is Part Of: Environmental pollution. Volume 306(2022)
• Publication Date: 2022-08-01
• Subjects: Perfluoroalkyl substance -- Breast cancer -- Case-cohort study -- Mixture effect -- Quantile g-computation approach; 8-OHdG 8-hydroxydeoxyguanosine -- BMI body mass index -- CI confidence interval -- DFTJ Dongfeng-Tongji -- DMC Dongfeng Motor Corporation -- GSH glutathione -- HR hazard ratio -- IARC International Agency for Research on Cancer -- LOD limit of detection -- MDA malondialdehyde -- PFAS perfluoroalkyl substance -- PFCA perfluorinated carboxylic acid -- PFDA perfluorodecanoic acid -- PFHpA perfluoroheptanoic acid -- PFHxS perfluorohexane sulfonic acid -- PFNA perfluorononanoic acid -- PFOA perfluorooctanoic acid -- PFOS perfluorooctane sulfonic acid -- PFSA perfluorinated sulfonic acid -- POP persistent organic pollutant -- ROS reactive oxygen specie -- SD standard deviation; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2022.119345
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: Experimental studies have suggested perfluoroalkyl substances (PFASs) as mammary toxicants, but few studies evaluated the prospective associations of PFASs with breast cancer risk. We performed a case-cohort study within the Dongfeng-Tongji cohort, including incident breast cancer cases (n = 226) and a random sub-cohort (n = 990). Baseline plasma concentrations of four perfluorinated carboxylic acids (PFCAs) [perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroheptanoic acid (PFHpA)] and two perfluorinated sulfonic acids (PFSAs) [perfluorooctane sulfonic acid (PFOS) and perfluorohexane sulfonic acid (PFHxS)] were measured. Barlow-weighted Cox regression models revealed that each 1-unit increase in ln-transformed PFOA and PFHpA was associated with a separate 35% and 20% elevated incident risk of breast cancer [HR(95%CI) = 1.35(1.03, 1.78) and 1.20(1.02, 1.40), respectively], which were also significant among postmenopausal females [HR(95%CI) = 1.34(1.01, 1.77) and 1.23 (1.02, 1.48), respectively]. Quantile g-computation analysis observed a 19% increased incident risk of breast cancer along with each simultaneous quartile increase in all ln-transformed PFCA concentrations [HR(95%CI) = 1.19(1.01, 1.41)], with PFOA accounting for 56% of the positive effect. Our findings firstly revealed the impact of short-chain PFHpA on increased incident risk of breast cancer, suggested exposure to PFASs as a risk factor for breast cancer, and shed light on breast cancer prevention by regulating PFASs as a chemical class. Graphical abstract: Image 1 Highlights: Prospective associations of PFASs with breast cancer risk remain largely unknown. PFOA, PFHpA, and ΣPFCA were positively associated with breast cancer risk. Quantile g-computation approach found mixture effect of PFCAs on breast cancer risk.