Clinical evaluation of anaesthetic‐like effect of two dermocosmetic formulations containing Aquaphilus dolomiae extract‐G3 in subjects with sensitive facial skin. (21st March 2022)

• Record Type: Journal Article
• Authors: Villaret, A.; Lestienne, F.; Vial, F.; Aubert, A.; Maret, A.; El Marbouh, L.; Bessou‐Touya, S.; Castex‐Rizzi, N.; Duplan, H.; Coubetergues, H.
• Is Part Of: Journal of the European Academy of Dermatology and Venereology. Volume 36:Number 5(2022)Supplement
• Page Start: 6
• Page End: 12
• Publication Date: 2022-03-21
• Subjects: Dermatology -- Periodicals; Sexually transmitted diseases -- Periodicals; 616.5
• DOI: 10.1111/jdv.17902
• Languages: English
• ISSNs: 0926-9959

Abstract

Abstract: Background: Sensitive skin is a common condition of hyper‐reactivity to external stimuli, e.g. heat or abrasion. The symptoms are subjective but can be measured using validated emotional and technical methods. Avène water has several beneficial effects on the skin. In vitro studies indicated that the active component of this natural spring water, Aquaphilus dolomiae extract‐G3 (ADE‐G3), modulates cutaneous sensitivity via an anaesthetic‐like mechanism. Objectives: To assess facial skin reactivity after repeated application of two formulations containing ADE‐G3. Methods: In open‐label studies, healthy subjects with sensitive facial skin applied cream or balm twice daily for 84 days. The severity of skin sensitivity was measured using the Sensitive Scale (based on quantifying visible or subjective signs). Subjective responses associated with pain or uncomfortable feeling were assessed by measuring electrodermal response (EDR). This involves measuring variations in skin electrical resistance due to non‐conscious physiological changes in activity of the sympathetic nervous system. Subjects were also evaluated for beneficial effects according to a quantitative approach using semantic assessment of a question regarding their skin quality. Evaluations were performed before and after the first application, and after 29/30, 56 and 84 days of twice daily use. Results: There was a significant decrease in the EDR after stimuli immediately after the application of both ADE‐G3 formulations, which continued to decrease over 84 days (40–50% decrease by D85). Likewise, all physical and functional signs of the Sensitive Scale were significantly decreased immediately after the first application and at all time points tested after treatment. Verbatim analysis revealed a semantic shift, from mainly negative terms on D1 to mainly positive terms at D85 for both tested products. Conclusions: These results demonstrated that two formulations containing ADE‐G3 reduced skin sensitivity, indicating a decreased activation of the sympathetic nervous system associated with this condition.