African-American Race Predicts 1-Year Cognitive Decline Among Adults Without Moderate Dementia. (17th December 2021)
- Record Type:
- Journal Article
- Title:
- African-American Race Predicts 1-Year Cognitive Decline Among Adults Without Moderate Dementia. (17th December 2021)
- Main Title:
- African-American Race Predicts 1-Year Cognitive Decline Among Adults Without Moderate Dementia
- Authors:
- Babiker, Niser
Gonzalez, Alan
Soto, Jovany
Shi, Chengjian
Rzhetsky, Andrey
Huisingh-Scheetz, Megan - Abstract:
- Abstract: Previous literature shows conflicting conclusions about the association between race and cognitive decline, particularly in early impairment. In this study, we aimed to test whether race predicted 1-year change in Montreal Cognitive Assessment (MoCA) score among older adults without moderate-severe dementia. We secondarily explored whether multimorbidity, polypharmacy, depressed mood, antidepressant use, body composition, or frailty changed the association. We analyzed data (n=122) from predominantly African American (AfA, 78.7%) community-dwelling older adults from the south side of Chicago. Participants underwent baseline and 1-year MoCA testing. Age, gender, race, education, monthly income, co-morbidities (Charlson Comorbidity Index), medication use (<5 vs ≥5), depression (PHQ-2), proportion lean mass (DEXA), and the frailty phenotype (range 0-5) were collected at baseline. In a multivariate linear model, we regressed 1-year MoCA score on baseline MoCA score, race, and demographics and then evaluated the impact of each covariate added separately to the model on the race-cognition relationship. The mean MoCA score at baseline was 25.2+/-0.2 (range 18-30) and 41.0% of participants experienced ≥1 point MoCA decline at 1 year. After adjusting for demographics, AfAs experienced a greater 1-year MoCA decline (β= -1.3, p=0.04) compared to other races. The effect size was unchanged after adjusting for multimorbidity and polypharmacy (β= -1.3, p=0.04), attenuatedAbstract: Previous literature shows conflicting conclusions about the association between race and cognitive decline, particularly in early impairment. In this study, we aimed to test whether race predicted 1-year change in Montreal Cognitive Assessment (MoCA) score among older adults without moderate-severe dementia. We secondarily explored whether multimorbidity, polypharmacy, depressed mood, antidepressant use, body composition, or frailty changed the association. We analyzed data (n=122) from predominantly African American (AfA, 78.7%) community-dwelling older adults from the south side of Chicago. Participants underwent baseline and 1-year MoCA testing. Age, gender, race, education, monthly income, co-morbidities (Charlson Comorbidity Index), medication use (<5 vs ≥5), depression (PHQ-2), proportion lean mass (DEXA), and the frailty phenotype (range 0-5) were collected at baseline. In a multivariate linear model, we regressed 1-year MoCA score on baseline MoCA score, race, and demographics and then evaluated the impact of each covariate added separately to the model on the race-cognition relationship. The mean MoCA score at baseline was 25.2+/-0.2 (range 18-30) and 41.0% of participants experienced ≥1 point MoCA decline at 1 year. After adjusting for demographics, AfAs experienced a greater 1-year MoCA decline (β= -1.3, p=0.04) compared to other races. The effect size was unchanged after adjusting for multimorbidity and polypharmacy (β= -1.3, p=0.04), attenuated slightly after adjusting for frailty (β= -1.2, p=0.06), depressed mood (β= -1.2, p=0.05), lean mass (β= -1.2, p=0.04), and attenuated notably after adjusting for antidepressant use (β= -1.0, p=0.11). Findings support the need to further explore racial differences in cognitive decline and potentially related anti-depressant underuse. … (more)
- Is Part Of:
- Innovation in aging. Volume 5(2021)Supplement 1
- Journal:
- Innovation in aging
- Issue:
- Volume 5(2021)Supplement 1
- Issue Display:
- Volume 5, Issue 1 (2021)
- Year:
- 2021
- Volume:
- 5
- Issue:
- 1
- Issue Sort Value:
- 2021-0005-0001-0000
- Page Start:
- 623
- Page End:
- 623
- Publication Date:
- 2021-12-17
- Subjects:
- Aging -- Periodicals
Gerontology -- Periodicals
612.67 - Journal URLs:
- https://academic.oup.com/innovateage ↗
http://www.oxfordjournals.org/ ↗ - DOI:
- 10.1093/geroni/igab046.2378 ↗
- Languages:
- English
- ISSNs:
- 2399-5300
- Deposit Type:
- Legaldeposit
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- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
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