Sustained‐release ibuprofen prodrug particle: Emulsifier and initiator regulate the diameter and distribution. Issue 5 (10th August 2020)

• Record Type: Journal Article
• Authors: Wang, Jia; Zhang, Haixin; Xu, Jie; Qian, Hao; Liu, Rui; Xu, Zengchang; Zhu, Hongjun
• Is Part Of: Journal of applied polymer science. Volume 138:Issue 5(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-08-10
• Subjects: drug delivery systems -- emulsion polymerization -- nanostructured polymers; Polymers -- Periodicals; Polymerization -- Periodicals; 668.9
• DOI: 10.1002/app.49779
• Languages: English
• ISSNs: 0021-8995

Abstract

Abstract: Polymers have played a vital part in the development of drug delivery systems (DDS). For DDS, having a controllable diameter and distribution are conducive to reproducibility of drug release behavior and efficacy. In this work, an ibuprofen prodrug (Ibu@PMMA) was synthesized by methyl methacrylate (MMA), ibuprofen monomer (Ibu@HEMA), and ethylene glycol dimethacrylate (EGDMA) via emulsion polymerization. The Ibu@PMMA exhibits spherical shapes, and its structural properties were characterized by NMR, FTIR, and SEM techniques. In addition, the hydrodynamic diameter and polydispersity index (PDI) of Ibu@PMMA were reduced by increasing the proportion of emulsifier. Meanwhile, by increasing the amount of initiator, the hydrodynamic diameter and PDI of Ibu@PMMA were decreased. Moreover, Ibu@PMMA exhibits good sustained‐release ability in vitro, which could be used as a potential delivery system for anti‐inflammatory agents. Abstract : An ibuprofen prodrug (Ibu@PMMA) was synthesized by methyl methacrylate, ibuprofen monomer and ethylene glycol dimethacrylate via emulsion polymerization. Diameter and distribution of Ibu@PMMA can be adjusted by changing the ratio of emulsifier and initiator. Moreover, Ibu@PMMA exhibits good sustained‐release ability in vitro..