MRI in Neuromuscular Diseases: An Emerging Diagnostic Tool and Biomarker for Prognosis and Efficacy. Issue 4 (1st July 2020)

• Record Type: Journal Article
• Authors: Dahlqvist, Julia R.; Widholm, Per; Leinhard, Olof Dahlqvist; Vissing, John
• Is Part Of: Annals of neurology. Volume 88:Issue 4(2020)
• Page Start: 669
• Page End: 681
• Publication Date: 2020-07-01
• Subjects: Neurology -- Periodicals; Pediatric neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; 616.8
• DOI: 10.1002/ana.25804
• Languages: English
• ISSNs: 0364-5134

Abstract

Abstract : There is an unmet need to identify biomarkers sensitive to change in rare, slowly progressive neuromuscular diseases. Quantitative magnetic resonance imaging (MRI) of muscle may offer this opportunity, as it is noninvasive and can be carried out almost independent of patient cooperation and disease severity. Muscle fat content correlates with muscle function in neuromuscular diseases, and changes in fat content precede changes in function, which suggests that muscle MRI is a strong biomarker candidate to predict prognosis and treatment efficacy. In this paper, we review the evidence suggesting that muscle MRI may be an important biomarker for diagnosis and to monitor change in disease severity. ANN NEUROL 2020;88:669–681