Magnesium Corrosion Triggered Spontaneous Generation of H2O2 on Oxidized Titanium for Promoting Angiogenesis. Issue 49 (20th October 2015)

• Record Type: Journal Article
• Authors: Park, Jimin; Du, Ping; Jeon, Jin‐Kyung; Jang, Gun Hyuk; Hwang, Mintai Peter; Han, Hyung‐Seop; Park, Kwideok; Lee, Kwan Hyi; Lee, Jee‐Wook; Jeon, Hojeong; Kim, Yu‐Chan; Park, Jong Woong; Seok, Hyun‐Kwang; Ok, Myoung‐Ryul
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 49(2015)
• Page Start: 14753
• Page End: 14757
• Publication Date: 2015-10-20
• Subjects: angiogenesis -- catalysis -- corrosion -- magnesium -- oxygen reduction reaction; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201507352
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Although the use of reactive oxygen species (ROS) has been extensively studied, current systems employ external stimuli such as light or electrical energy to produce ROS, which limits their practical usage. In this report, biocompatible metals were used to construct a novel electrochemical system that can spontaneously generate H2 O2 without any external light or voltage. The corrosion of Mg transfers electrons to Au‐decorated oxidized Ti in an energetically favorable process, and the spontaneous generation of H2 O2 in an oxygen reduction reaction was revealed to occur at titanium by combined spectroscopic and electrochemical analyses. The controlled release of H2 O2 noticeably enhanced in vitro angiogenesis even in the absence of growth factors. Finally, a new titanium implant prototype was developed by Mg incorporation, and its potential for promoting angiogenesis was demonstrated. Abstract : Useful corrosion : An electrochemical system consisting of a biodegradable metal (Mg) and an oxygen‐reduction‐reaction catalyst was developed for spontaneous H2 O2 generation. The controlled release of H2 O2 promoted in vitro angiogenesis in the absence of any growth factors. A conventional titanium implant functionalized by simple magnesium incorporation thus also supports angiogenesis.