Outcomes following intra-amniotic instillation with indigo carmine to diagnose prelabor rupture of membranes in singleton pregnancies: a single center experience. (16th February 2016)

• Record Type: Journal Article
• Authors: Adekola, Henry; Gill, Navleen; Sakr, Sharif; Hobson, Deslyn; Bryant, David; Abramowicz, Jacques S.; Soto, Eleazar
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 29:Number 4(2016)
• Page Start: 544
• Page End: 549
• Publication Date: 2016-02-16
• Subjects: Amniodye test -- amniotic fluid culture -- amniotic fluid interleukin-6 concentration -- conventional tests -- placental pathology; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.3109/14767058.2015.1015982
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Objective : To evaluate clinical outcomes of women with singleton pregnancies that underwent intra-amniotic dye instillation (amniodye test) following equivocal diagnosis of prelabor rupture of membranes (PROM). Method : Records of 34 pregnant women who underwent amniodye test for equivocal PROM were reviewed. Comparisons of characteristics, amniotic fluid (AF) cultures, AF interleukin (IL)-6 concentrations, and placenta pathology results between women who tested positive and those who tested negative were performed. A sub-analysis of women who were amniodye test-negative was also performed. Results : (1) Commonest indication for amniodye test was a typical history of PROM with positive conventional tests and persistently normal AF volume, (2) amniodye test-positive women had a shorter procedure-to-delivery interval ( p = 0.008), and a greater proportion of histologic acute chorioamnionitis ( p = 0.04) and funisitis ( p = 0.01) than amniodye-negative women, and (3) in addition to similarities to women with amniodye-positive test, amniodye test-negative women who delivered <34 weeks, had a greater proportion of women with risk for preterm birth ( p = 0.04), than their counterparts who delivered between 34 0/7 and 36 6/7 weeks. Conclusion : Equivocal diagnosis of PPROM should warrant an amniodye test to avoid iatrogenic intervention in women with intact amniotic membranes. AF analysis should be performed in amniodye test-negative women.