Peptide–Oleate Complexes Create Novel Membrane-Bound Compartments. (10th June 2020)

• Record Type: Journal Article
• Authors: Hansen, Jesper S; Tran, Tuan Hiep; Cavalera, Michele; Paul, Sanchari; Chaudhuri, Arunima; Lindkvist-Petersson, Karin; Ho, James C S; Svanborg, Catharina
• Editors: Ozkan, Banu
• Is Part Of: Molecular biology and evolution. Volume 37:Number 11(2020)
• Page Start: 3083
• Page End: 3093
• Publication Date: 2020-06-10
• Subjects: cell division -- protocells -- giant unilamellar vesicles -- oleic acid -- peptides -- peptide–oleate complexes -- phospholipids; Molecular biology -- Periodicals; Molecular evolution -- Periodicals; Evolution, Molecular -- Periodicals; Molecular Biology -- Periodicals; 572.8
• DOI: 10.1093/molbev/msaa138
• Languages: English
• ISSNs: 0737-4038

Abstract

Abstract: A challenging question in evolutionary theory is the origin of cell division and plausible molecular mechanisms involved. Here, we made the surprising observation that complexes formed by short alpha-helical peptides and oleic acid can create multiple membrane-enclosed spaces from a single lipid vesicle. The findings suggest that such complexes may contain the molecular information necessary to initiate and sustain this process. Based on these observations, we propose a new molecular model to understand protocell division.