Frontispiece: Exploring the Biocatalytic Potential of Fe/α‐Ketoglutarate‐Dependent Halogenases. Issue 33 (10th June 2020)

• Record Type: Journal Article
• Authors: Voss, Moritz; Honda Malca, Sumire; Buller, Rebecca
• Is Part Of: Chemistry. Volume 26:Issue 33(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-06-10
• Subjects: biocatalysis -- C−H activation -- enzyme engineering -- Fe/alpha-KG-dependent halogenase -- genome mining; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202083361
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : Freestanding Fe/α‐ketoglutarate‐dependent halogenases are interesting development targets as they may serve as valuable tools for the synthesis of high‐value compounds. To date, a small number of indole alkaloid and amino acid halogenases have been identified and characterized. Initial enzyme engineering examples indicate that the accessible substrate range of these enzymes may be expanded whereas their throughout biophysical characterization continues to inform about the principles governing the halogenation mechanism. For more information see the Concept article by R. Buller et al. on page 7336 ff.