Development of a System for Postmarketing Population Pharmacokinetic and Pharmacodynamic Studies Using Real‐World Data From Electronic Health Records. Issue 4 (11th February 2020)

• Record Type: Journal Article
• Authors: Choi, Leena; Beck, Cole; McNeer, Elizabeth; Weeks, Hannah L.; Williams, Michael L.; James, Nathan T.; Niu, Xinnan; Abou‐Khalil, Bassel W.; Birdwell, Kelly A.; Roden, Dan M.; Stein, C. Michael; Bejan, Cosmin A.; Denny, Joshua C.; Van Driest, Sara L.
• Is Part Of: Clinical pharmacology & therapeutics. Volume 107:Issue 4(2020)
• Page Start: 934
• Page End: 943
• Publication Date: 2020-02-11
• Subjects: Pharmacology -- Periodicals; Therapeutics -- Periodicals; 615.5
• DOI: 10.1002/cpt.1787
• Languages: English
• ISSNs: 0009-9236

Abstract

Abstract : Postmarketing population pharmacokinetic (PK) and pharmacodynamic (PD) studies can be useful to capture patient characteristics affecting PK or PD in real‐world settings. These studies require longitudinally measured dose, outcomes, and covariates in large numbers of patients; however, prospective data collection is cost‐prohibitive. Electronic health records (EHRs) can be an excellent source for such data, but there are challenges, including accurate ascertainment of drug dose. We developed a standardized system to prepare datasets from EHRs for population PK/PD studies. Our system handles a variety of tasks involving data extraction from clinical text using a natural language processing algorithm, data processing, and data building. Applying this system, we performed a fentanyl population PK analysis, resulting in comparable parameter estimates to a prior study. This new system makes the EHR data extraction and preparation process more efficient and accurate and provides a powerful tool to facilitate postmarketing population PK/PD studies using information available in EHRs.