Beyond the Randomized Clinical Trial: Innovative Data Science to Close the Pediatric Evidence Gap. Issue 4 (22nd January 2020)

• Record Type: Journal Article
• Authors: Goulooze, Sebastiaan C.; Zwep, Laura B.; Vogt, Julia E.; Krekels, Elke H.J.; Hankemeier, Thomas; van den Anker, John N.; Knibbe, Catherijne A.J.
• Is Part Of: Clinical pharmacology & therapeutics. Volume 107:Issue 4(2020)
• Page Start: 786
• Page End: 795
• Publication Date: 2020-01-22
• Subjects: Pharmacology -- Periodicals; Therapeutics -- Periodicals; 615.5
• DOI: 10.1002/cpt.1744
• Languages: English
• ISSNs: 0009-9236

Abstract

Abstract : Despite the application of advanced statistical and pharmacometric approaches to pediatric trial data, a large pediatric evidence gap still remains. Here, we discuss how to collect more data from children by using real‐world data from electronic health records, mobile applications, wearables, and social media. The large datasets collected with these approaches enable and may demand the use of artificial intelligence and machine learning to allow the data to be analyzed for decision making. Applications of this approach are presented, which include the prediction of future clinical complications, medical image analysis, identification of new pediatric end points and biomarkers, the prediction of treatment nonresponders, and the prediction of placebo‐responders for trial enrichment. Finally, we discuss how to bring machine learning from science to pediatric clinical practice. We conclude that advantage should be taken of the current opportunities offered by innovations in data science and machine learning to close the pediatric evidence gap.