Angiotensin II and taste sensitivity. Issue 2 (May 2015)

• Record Type: Journal Article
• Authors: Shigemura, Noriatsu
• Is Part Of: Japanese dental science review. Volume 51:Issue 2(2015:May)
• Page Start: 51
• Page End: 58
• Publication Date: 2015-05
• Subjects: ALDO aldosterone -- ANG II angiotensin II -- AT1 (AT2) angiotensin II receptor type 1 (type 2) -- CB1 cannabinoid receptor 1 -- CT chorda tympani -- ENaC epithelial sodium channel -- GFP green fluorescent protein -- HCl hydrochloric acid -- i.p intraperitoneal -- KCl potassium chloride -- KO knockout -- MSG monosodium glutamate -- NaCl sodium chloride -- Pkd2L1 polycystic kidney disease 2-like 1 -- QHCl quinine hydrochloride -- RT-PCR reverse transcriptase polymerase chain reaction -- SNAP25 synaptosomal-associated protein 25 -- T1r3 taste receptor family 1 member 3 -- Trpm5 transient receptor potential cation channel subfamily M member 5; Taste -- Angiotensin II -- Aldosterone -- Amiloride -- AT1 -- ENaC -- T1r3; Dentistry -- Periodicals; Dentistry -- Japan -- Periodicals; 617.6005
• DOI: 10.1016/j.jdsr.2014.09.005
• Languages: English
• ISSNs: 1882-7616

Abstract

Summary: The sense of taste plays a major role in evaluating the quality of food components in the oral cavity. Sweet, salty, umami, sour and bitter taste are generally accepted as five basic taste qualities. Among them, salty taste is attractive to animals and influences sodium intake. Angiotensin II (ANG II) and aldosterone (ALDO, which is stimulated by ANG II) are key hormones that regulate sodium homeostasis and water balance. At the peripheral gustatory organs, it has been reported that ALDO increases the amiloride-sensitivity of the rat gustatory neural responses to NaCl in a time course of several hours. A recent study demonstrated that ANG II suppresses amiloride-sensitivity of the mouse gustatory and behavioral responses to NaCl via its receptor AT1 within an hour. Moreover, ANG II enhances sweet taste sensitivity without affecting umami, sour and bitter tastes. These results suggest that the reciprocal and sequential regulatory mechanisms by ANG II (as an acute suppressor) together with ALDO (as a slow enhancer) on the salt taste sensitivity may exist in peripheral taste organs, contribute to salt intake, and play an important role in sodium homeostasis. Furthermore, the linkage between salty and sweet taste modulations via the ANG II signaling may optimize sodium and calorie intakes.