Clinical characteristics of subglottic cancer: emphasis on therapeutic management strategies for stage II subglottic cancer*. (1st September 2020)

• Record Type: Journal Article
• Authors: Komatsubara, Yasutoshi; Tachibana, Tomoyasu; Orita, Yorihisa; Makino, Takuma; Kuroda, Kazunori; Naoi, Yuto; Kataoka, Yuko; Sato, Yasuharu; Kariya, Shin; Nishizaki, Kazunori
• Is Part Of: Acta oto-laryngologica. Volume 140:Number 9(2020)
• Page Start: 765
• Page End: 770
• Publication Date: 2020-09-01
• Subjects: Radiotherapy -- stage II -- subglottic cancer; Otolaryngology -- Periodicals; Ear -- Diseases -- Periodicals; Throat -- Diseases -- Periodicals; Otolaryngology -- Electronic Resources; Otorhinolaryngologic Diseases; 617.8
• DOI: 10.1080/00016489.2020.1767303
• Languages: English
• ISSNs: 0001-6489

Abstract

Abstract: Background: Subglottic cancer (SGC) is extremely rare, as most laryngeal cancers are localized to the glottic region. Accordingly, the clinical characteristics of SGC have not been well characterized. Objectives: In the current study, SGCs were clinically evaluated, and the outcomes of radiotherapy (RT) in patients with stage II SGC were assessed. Materials and Methods: Medical data derived from 11 patients with SGC, who were treated at our hospital between 1995 and 2019, were retrospectively reviewed. Results: In our department SGC accounted for 3.9% of the 280 laryngeal cancer patients treated during the study period. At the time of SGC diagnosis, 9 (81.8%) had stage II cancer, 1 had stage III cancer, and 1 had stage IV cancer. Stage II SGC patients treated with concurrent chemoradiotherapy (CCRT) showed a significantly higher local control rate ( p = .026) and laryngeal dysfunction free rate ( p = .026) than those treated with RT alone. Salvage surgery, performed in 4 patients whose disease was not locally controlled with CCRT/RT, was successful in 3 patients. Conclusion: As a treatment strategy for stage II SGC, CCRT is an acceptable initial treatment for laryngeal function and preservation while salvage surgery is effective for recurrence after CCRT/RT treatment.