Recovery kinetics of creatine in mild plantar flexion exercise using 3D creatine CEST imaging at 7 Tesla. Issue 2 (15th August 2020)

• Record Type: Journal Article
• Authors: Kumar, Dushyant; Nanga, Ravi Prakash Reddy; Thakuri, Deepa; Wilson, Neil; Cember, Abigail; Martin, Melissa Lynne; Zhu, Dan; Shinohara, Russell T.; Qin, Qin; Hariharan, Hari; Reddy, Ravinder
• Is Part Of: Magnetic resonance in medicine. Volume 85:Issue 2(2021)
• Page Start: 802
• Page End: 817
• Publication Date: 2020-08-15
• Subjects: creatine -- creatine CEST -- creatine kinase -- creatine recovery kinetics -- phosphocreatine -- plantar flexion exercise; Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.28463
• Languages: English
• ISSNs: 0740-3194

Abstract

Abstract : Purpose: Two‐dimensional creatine CEST (2D‐CrCEST), with a slice thickness of 10‐20 mm and temporal resolution (τRes ) of about 30 seconds, has previously been shown to capture the creatine‐recovery kinetics in healthy controls and in patients with abnormal creatine‐kinase kinetics following the mild plantar flexion exercise. Since the distribution of disease burden may vary across the muscle length for many musculoskeletal disorders, there is a need to increase coverage in the slice‐encoding direction. Here, we demonstrate the feasibility of 3D‐CrCEST with τRes of about 30 seconds, and propose an improved voxel‐wise B 1 + ‐calibration approach for CrCEST. Methods: The current 7T study with enrollment of 5 volunteers involved collecting the baseline CrCEST imaging for the first 2 minutes, followed by 2 minutes of plantar flexion exercise and then 8 minutes of postexercise CrCEST imaging, to detect the temporal evolution of creatine concentration following exercise. Results: Very good repeatability of 3D‐CrCEST findings for activated muscle groups on an intraday and interday basis was established, with coefficient of variance of creatine recovery constants (τCr ) being 7%‐15.7%, 7.5%, and 5.8% for lateral gastrocnemius, medial gastrocnemius, and peroneus longus, respectively. We also established a good intraday and interday scan repeatability for 3D‐CrCEST and also showed good correspondence between τCr measurements using 2D‐CrCEST and 3D‐CrCEST acquisitions. Conclusion: In this study, we demonstrated for the first time the feasibility and the repeatability of the 3D‐CrCEST method in calf muscle with improved B 1 + correction to measure creatine‐recovery kinetics within a large 3D volume of calf muscle.