Isoflurane decreases substantia gelatinosa neuron excitability and synaptic transmission from periphery in the rat spinal dorsal horn. Issue 2 (13th January 2021)

• Record Type: Journal Article
• Authors: Yang, Dakai; Yang, Xingwu J.; Shao, Caifeng; Yang, Kun
• Is Part Of: NeuroReport. Volume 32:Issue 2(2021)
• Publication Date: 2021-01-13
• Subjects: anesthesia -- isoflurane -- patch-clamp -- spinal cord -- substantia gelatinosa; Neurosciences -- Periodicals; Nervous system -- Periodicals; Neurophysiology -- Periodicals; Nervous System Diseases -- Periodicals; Nervous System Physiological Phenomena -- Periodicals; Neurosciences -- Periodicals; 616.805
• DOI: 10.1097/WNR.0000000000001557
• Languages: English
• ISSNs: 0959-4965

Abstract

Abstract : Isoflurane is an inhaled anesthetic, though its actions at the cellular level remain controversial. By using acute spinal cord slices from adult rats and the whole-cell recording technique, we found that aqueous isoflurane at the minimum alveolar concentration decreased postsynaptic neural excitability and enhanced membrane conductance, while suppressing glutamate release from presynaptic afferent onto substantia gelatinosa (lamina II) neurons in the dorsal horn. The data demonstrate that isoflurane modulates synaptic transmission from peripheral to the spinal cord via both pre- and postsynaptic effects and these actions may underlie its spinal anesthesia.