Recent developments in antimicrobial therapy for gastrointestinal infections. Issue 1 (January 2021)

• Record Type: Journal Article
• Authors: Carlson, Travis J.; Gonzales-Luna, Anne J.; Garey, Kevin W.
• Is Part Of: Current opinion in gastroenterology. Volume 37:Issue 1(2021)
• Publication Date: 2021-01
• Subjects: Clostridioides difficile -- Clostridium difficile -- cryptosporidium -- cytomegalovirus -- diarrhea -- gastroenteritis -- gastrointestinal infections -- Helicobacter pylori; Gastroenterology -- Periodicals; 616.33
• DOI: 10.1097/MOG.0000000000000696
• Languages: English
• ISSNs: 0267-1379

Abstract

Abstract : Purpose of review: This focused, narrative review summarizes human clinical trial data for direct-acting antimicrobials in development for the treatment of gastrointestinal infections that were published in the past 18 months (1 January 2019 to 30 June 2020). Recent findings: Antimicrobial agents for Clostridioides difficile infection ( n = 6), cryptosporidiosis ( n = 1), cytomegalovirus infection ( n = 3) and Helicobacter pylori infection ( n = 1) have completed and/or are undergoing human clinical trials. Summary: Although this review highlights significant advances in four disease states, many common gastrointestinal pathogens have no antimicrobials in human clinical trials, emphasizing the need for continued prioritization in this field of study.