High 18F-FDOPA PET Uptake in Primary Central Nervous System Lymphoma. (January 2021)

• Record Type: Journal Article
• Authors: Salgues, Betty; Kaphan, Elsa; Molines, Elicia; Brun, Gilles; Guedj, Eric
• Is Part Of: Clinical nuclear medicine. Volume 46:Number 1(2021)
• Publication Date: 2021-01
• Subjects: 18F-FDOPA PET -- LAT1 -- primary central nervous system lymphoma; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000003303
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: We present a 42-year-old woman with primary central nervous system lymphoma (PCNSL) and strong 18 F-FDOPA PET uptake. 18 F-FDOPA PET has high diagnostic accuracy in gliomas and brain metastases. The L-type amino acid transporter 1, targeted by 18 F-FDOPA and 11 C-MET PET, is a cell-type transporter usually upregulated in malignant tumors, including PCNSL. In this line, strong uptake was already shown with 11 C-MET in PCNSL. We report the same findings with 18 F-FDOPA. Consequently, PCNSL is a possible differential neoplastic diagnosis of 18 F-FDOPA uptake among neoplastic lesions.