Quantification of Hepatic Fat Fraction in Patients With Nonalcoholic Fatty Liver Disease: Comparison of Multimaterial Decomposition Algorithm and Fat (Water)-Based Material Decomposition Algorithm Using Single-Source Dual-Energy Computed Tomography. Issue 1 (January 2021)

• Record Type: Journal Article
• Authors: Zhang, Qinhe; Zhao, Ying; Wu, Jingjun; Xie, Luhan; Chen, Anliang; Liu, Yijun; Song, Qingwei; Li, Jianying; Wu, Tingfan; Xie, Lizhi; Liu, Ailian
• Is Part Of: Journal of computer assisted tomography. Volume 45:Issue 1(2021)
• Publication Date: 2021-01
• Subjects: multimaterial decomposition -- computed tomography -- nonalcoholic fatty liver disease -- quantitative -- fat; Tomography -- Periodicals; Tomography -- Periodicals; Tomography; Periodicals; 616.0757
• DOI: 10.1097/RCT.0000000000001112
• Languages: English
• ISSNs: 0363-8715

Abstract

Objective: The purpose of this study was to evaluate the accuracy of quantifying hepatic fat fraction (HFF) in nonalcoholic fatty liver disease patients with multimaterial decomposition (MMD) and fat (water)-based material decomposition by single-source dual-energy computed tomography. Methods: Hepatic fat fractions were quantified by noncontrast (HFFnon-CE ) and contrast-enhanced single-source dual-energy computed tomography in arterial phase (HFFAP ), portal venous phase (HFFPVP ) and equilibrium phase (HFFEP ) using MMD in 19 nonalcoholic fatty liver disease patients. The fat concentration was measured on fat (water)-based images. As the standard of reference, magnetic resonance iterative decomposition of water and fat with echo asymmetry and least-squares estimation-iron quantification images were reconstructed to obtain HFF (HFFIDEAL-IQ ). Results: There was a strong correlation between HFFnon-CE, HFFAP, HFFPVP, HFFEP, fat concentration and HFFIDEAL-IQ ( r = 0.943, 0.923, 0.942, 0.952, and 0.726) with HFFs having better correlation with HFFIDEAL-IQ . Hepatic fat fractions did not significantly differ across scanning phases. The HFFs of 3-phase contrast-enhanced computed tomography had a good consistency with HFFnon-CE . Conclusions: Hepatic fat fraction using MMD has excellent correlation with that of magnetic resonance imaging, is independent of the computed tomography scanning phases, and may be used as a routine technique for quantitative assessment of HFF.