Exosome: From leukemia progression to a novel therapeutic approach in leukemia treatment. (14th August 2020)

• Record Type: Journal Article
• Authors: Gholipour, Elham; Sarvarian, Parisa; Samadi, Parisa; Talebi, Mehdi; Movassaghpour, Aliakbar; Motavalli, Roza; Hojjat‐Farsangi, Mohammad; Yousefi, Mehdi
• Is Part Of: BioFactors. Volume 46:Number 5(2020)
• Page Start: 698
• Page End: 715
• Publication Date: 2020-08-14
• Subjects: biomarker -- drug delivery -- immunotherapy -- miRNA -- stem cell -- tumor‐derived exosome -- vaccination; Vitamins -- Physiological effect -- Periodicals; Trace elements -- Physiological effect -- Periodicals; Growth factors -- Physiological effect -- Periodicals; Plant growth promoting substances -- Physiological effect -- Periodicals; Biochemistry -- Periodicals; Nutritional Physiological Phenomena -- Periodicals; Trace Elements -- metabolism -- Periodicals; Vitamins -- metabolism -- Periodicals; Molecular Biology -- Periodicals; 612.399
• DOI: 10.1002/biof.1669
• Languages: English
• ISSNs: 0951-6433

Abstract

Abstract: Exosomes, as small vesicles, are released by tumor cells and tumor microenvironment (cells and function as key intercellular mediators and effects on different processes including tumorigenesis, angiogenesis, drug resistance, and evasion from immune system. These functions are due to exosomes' biomolecules which make them as efficient markers in early diagnosis of the disease. Also, exosomes have been recently applied in vaccination. The potential role of exosomes in immune response toward leukemic cells makes them efficient immunotherapeutic agents treating leukemia. Furthermore, variations in exosomes contents make them beneficial to be used in treating different diseases. This review introduces the role of exosomes in the development of hematological malignancies and evaluates their functional role in the treatment of these malignancies.