Anti-glomerular Basement Membrane Disease: What Have We Learned?. (January 2021)

• Record Type: Journal Article
• Authors: Akhtar, Mohammed; Taha, Noheir M.; Asim, Muhammad
• Is Part Of: Advances in anatomic pathology. Volume 28:Number 1(2021)
• Publication Date: 2021-01
• Subjects: anti-GBM -- glomerulonephritis -- pulmonary hemorrhage -- antigen -- crescentic glomerulonephritis -- pathogenesis -- ANCA; Pathology -- Periodicals; 616.0705
• DOI: 10.1097/PAP.0000000000000280
• Languages: English
• ISSNs: 1072-4109

Abstract

Abstract : Since the first clinicopathologic description by Ernest Goodpasture of a patient whom he considered to have died of influenza in 1919, substantial progress has been made in our knowledge of anti-glomerular basement membrane disease. This has led to a significant decrease in the morbidity and mortality associated with this disease. In this paper, we aim to review the literature that has enhanced our understanding of classic anti-glomerular basement membrane disease and its clinic-pathologic variants in the key areas of immunopathogenesis and histopathology. We also summarize varied clinical presentations and therapeutic strategies. Abstract : Supplemental Digital Content is available in the text.