The association between hypertension and colorectal cancer: a meta-analysis of observational studies. Issue 1 (January 2021)

• Record Type: Journal Article
• Authors: Xuan, Kun; Zhao, Tianming; Sun, Chenyu; Patel, Akash S.; Liu, Haixia; Chen, Xin; Qu, Guangbo; Sun, Yehuan
• Is Part Of: European journal of cancer prevention. Volume 30:Issue 1(2021)
• Publication Date: 2021-01
• Subjects: colorectal cancer -- hypertension -- meta-analysis; Cancer -- Prevention -- Periodicals; Neoplasms -- etiology -- Periodicals; Neoplasms -- prevention & control -- Periodicals; Cancer -- Prevention; Periodicals; 616.994052
• DOI: 10.1097/CEJ.0000000000000578
• Languages: English
• ISSNs: 0959-8278

Abstract

Abstract : The relationship between hypertension and risk of colorectal cancer (CRC) is unclear. This meta-analysis aims to explore the association between them. Six databases were searched for studies published before August 2019. The pooled relative risk (RR) and 95% confidence intervals (CIs) were calculated to estimate the association between the hypertension and CRC risk. A total of 2841 potentially relevant articles were obtained, and 25 studies with a pooled 1.95 million participants were finally included in the meta-analysis. These results suggested a positive association between hypertension and risk of CRC with a pooled RR of 1.15 (95% CI: 1.08, 1.23). Male patients with hypertension had a 13% (95% CI: 1.06, 1.20) increased risk of CRC. The risk of colon cancer and rectal cancer in male patients was 1.17 (95% CI: 1.01, 1.36) and 1.35 (95% CI: 1.04, 1.74), respectively, while no association between hypertension and the risk of CRC in females was elucidated. This meta-analysis demonstrated that a positive association between hypertension and CRC exists, with male patients having a higher risk of developing CRC than female patients.