Blood Substitutes and Oxygen Therapeutics: A Review. (January 2021)

• Record Type: Journal Article
• Authors: Jahr, Jonathan S.; Guinn, Nicole R; Lowery, David R.; Shore-Lesserson, Linda; Shander, Aryeh
• Is Part Of: Anesthesia & analgesia. Volume 132:(2021)Supplement 1 3S
• Publication Date: 2021-01
• Subjects: Anesthesiology -- Periodicals; Anesthesia; Anesthesiology; Analgesia; Analgesics; Anesthesiology -- Periodicals; 617.9605
• DOI: 10.1213/ANE.0000000000003957
• Languages: English
• ISSNs: 0003-2999

Abstract

Abstract : Despite the exhaustive search for an acceptable substitute to erythrocyte transfusion, neither chemical-based products such as perfluorocarbons nor hemoglobin-based oxygen carriers have succeeded in providing a reasonable alternative to allogeneic blood transfusion. However, there remain scenarios in which blood transfusion is not an option, due to patient's religious beliefs, inability to find adequately cross-matched erythrocytes, or in remote locations. In these situations, artificial oxygen carriers may provide a mortality benefit for patients with severe, life-threatening anemia. This article provides an up-to-date review of the history and development, clinical trials, new technology, and current standing of artificial oxygen carriers as an alternative to transfusion when blood is not an option.