Photopenic Defects in Gliomas With Amino-Acid PET and Relative Prognostic Value: A Multicentric 11C-Methionine and 18F-FDOPA PET Experience. (January 2021)

• Record Type: Journal Article
• Authors: Zaragori, Timothée; Castello, Angelo; Guedj, Eric; Girard, Antoine; Galldiks, Norbert; Albert, Nathalie L.; Lopci, Egesta; Verger, Antoine
• Is Part Of: Clinical nuclear medicine. Volume 46:Number 1(2021)
• Publication Date: 2021-01
• Subjects: 11C-MET -- 18F-FDOPA -- glioma -- photopenic -- prognosis; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000003240
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: The aim is to explore the concept of photopenic defects in newly diagnosed glioma patients with the 2 widely used 11 C-MET and 18 F-FDOPA PET amino acid tracers. Thirty-two 11 C-MET and 26 18 F-FDOPA PET scans with amino acid PET-negative gliomas were selected in this European multicentric study. Of these gliomas, 16 11 C-MET and 10 18 F-FDOPA PET scans with photopenic defects were identified, exhibiting lower mean tumor-to-background ratio as compared with isometabolic gliomas ( P < 0.001). Gliomas with photopenic defects had no different progression-free survival than isometabolic gliomas in the whole population ( P = 0.40), but shorter progression-free survival in the subgroup of World Health Organization grade II IDH-mutant astrocytomas (35 vs 68 months; P = 0.047).