Cover Feature: Further Investigations into Rigidity‐Activity Relationships in BisQAC Amphiphilic Antiseptics (ChemMedChem 8/2020). (16th April 2020)

• Record Type: Journal Article
• Authors: Leitgeb, Austin J.; Feliciano, Javier A.; Sanchez, Hugo A.; Allen, Ryan A.; Morrison, Kelly R.; Sommers, Kyle J.; Carden, Robert G.; Wuest, William M.; Minbiole, Kevin P. C.
• Is Part Of: ChemMedChem. Volume 15:Number 8(2020)
• Page Start: 660
• Page End: 660
• Publication Date: 2020-04-16
• Subjects: antiseptics -- quaternary ammonium compounds -- methicillin-resistant Staphylococcus aureus (MRSA) -- bisQACs; Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.202000182
• Languages: English
• ISSNs: 1860-7179

Abstract

Abstract : The Cover Feature shows the application of a disinfectant on a surface in a hospital setting, while a child plays nearby. The development of novel disinfectants is crucial to inhibiting the transmission of human pathogens in a variety of locations. Wuest, Minbiole, and coworkers are working to develop a better understanding of how novel multicationic quaternary ammonium compounds (QACs) might best eradicate a variety of bacteria, including those exhibiting resistance. The effects of structural rigidity of the biscationic QAC compounds is investigated. Original illustration by Orlena Roe. More information can be found in the Communication by Austin J. Leitgeb, William M. Wuest, Kevin P. C. Minbiole et al. .