Comparison of single breath hyperpolarized 129Xe MRI with dynamic 19F MRI in cystic fibrosis lung disease. Issue 2 (8th August 2020)

• Record Type: Journal Article
• Authors: McCallister, Andrew; Chung, Sang Hun; Antonacci, Michael; Z. Powell, Margret; Ceppe, Agathe S.; Donaldson, Scott H.; Lee, Yueh Z.; Branca, Rosa Tamara; Goralski, Jennifer L.
• Is Part Of: Magnetic resonance in medicine. Volume 85:Issue 2(2021)
• Page Start: 1028
• Page End: 1038
• Publication Date: 2020-08-08
• Subjects: cystic fibrosis -- hyperpolarized gas -- perflorinated gas imaging -- VDP -- ventilation defect; Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.28457
• Languages: English
• ISSNs: 0740-3194

Abstract

Abstract : Purpose: To quantitatively compare dynamic 19 F and single breath hyperpolarized 129 Xe MRI for the detection of ventilation abnormalities in subjects with mild cystic fibrosis (CF) lung disease. Methods: Ten participants with stable CF and a baseline FEV1 > 70% completed a single imaging session where dynamic 19 F and single breath 129 Xe lung ventilation images were acquired on a 3T MRI scanner. Ventilation defect percentages (VDP) values between 19 F early‐breath, 19 F maximum‐ventilation, 129 Xe low‐resolution, and 129 Xe high‐resolution images were compared. Dynamic 19 F images were used to determine gas wash‐in/out rates in regions of ventilation congruency and mismatch between 129 Xe and 19 F. Results: VDP values from high‐resolution 129 Xe images were greater than from low‐resolution images ( P = .001), although these values were significantly correlated (r = 0.68, P = .03). Early‐breath 19 F VDP and max‐vent 19 F VDP also showed significant correlation (r = 0.75, P = .012), with early‐breath 19 F VDP values being significantly greater ( P < .001). No correlation in VDP values were detected between either 19 F method or high‐res 129 Xe images. In addition, the location and volume of ventilation defects were often different when comparing 129 Xe and 19 F images from the same subject. Areas of ventilation congruence displayed the expected ventilation kinetics, while areas of ventilation mismatch displayed abnormally slow gas wash‐in and wash‐out. Conclusion: In CF subjects, ventilation abnormalities are identified by both 19 F and HP 129 Xe imaging. However, these ventilation abnormalities are not entirely congruent. 19 F and HP 129 Xe imaging provide complementary information that enable differentiation of normally ventilated, slowly ventilated, and non‐ventilated regions in the lungs.