Therapeutic Potential of Extracellular Vesicles in Hypertension-Associated Kidney Disease. Issue 1 (January 2021)

• Record Type: Journal Article
• Authors: Martinez-Arroyo, Olga; Ortega, Ana; Redon, Josep; Cortes, Raquel
• Is Part Of: Hypertension. Volume 77:Issue 1(2021)
• Publication Date: 2021-01
• Subjects: exosomes -- extracellular vesicles -- hypertension -- kidney diseases -- therapeutics; Hypertension -- Periodicals; Hypertension -- Treatment -- Periodicals; 616.132005
• DOI: 10.1161/HYPERTENSIONAHA.120.16064
• Languages: English
• ISSNs: 0194-911X

Abstract

Abstract : Hypertension-mediated organ damage frequently includes renal function decline in which several mechanisms are involved. The present review outlines the state of the art on extracellular vesicles in hypertension and hypertension-related renal damage. Emerging evidence indicates that extracellular vesicles, small vesicles secreted by most cell types and body fluids, are involved in cell-to-cell communication and are key players mediating biological processes such as inflammation, endothelial dysfunction or fibrosis, mechanisms present the onset and progression of hypertension-associated kidney disease. We address the potential use of extracellular vesicles as markers of hypertension-mediated kidney damage severity and their application as therapeutic agents in hypertension-associated renal damage. The capacity of exosomes to deliver a wide variety of cargos to the target cell efficiently makes them a potential drug delivery system for treatment of renal diseases.