Heterogeneous presentation of caspr2 antibody‐associated peripheral neuropathy – A case series. (30th April 2020)

• Record Type: Journal Article
• Authors: Ellwardt, Erik; Geber, Christian; Lotz, Johannes; Birklein, Frank
• Is Part Of: European journal of pain. Volume 24:Number 7(2020)
• Page Start: 1411
• Page End: 1418
• Publication Date: 2020-04-30
• Subjects: Pain -- Periodicals; Pain -- Treatment -- Periodicals; Pain -- Physiological aspects -- Periodicals; 616.0472
• DOI: 10.1002/ejp.1572
• Languages: English
• ISSNs: 1090-3801

Abstract

Abstract: Contactin‐associated protein 2–like (caspr2) antibodies have been discovered recently. Since then a multitude of patients with caspr2 antibodies presenting with different neurological symptoms have been reported. Here, we describe three patients with caspr2 antibodies with different types of pain/no pain in combination with peripheral neuropathy. The first patient, a 33‐year‐old woman, presented with erythromelalgia‐like pain and autonomic symptoms; the second patient, a 58‐year‐old man, with paresthesia and pain while walking together with signs of peripheral motor neuron hyperexcitability in combination with optic neuritis, and the third patient, a 74‐year‐old man, without any pain but with polyneuropathy and encephalopathy. These cases illustrate the spectrum of symptoms in anti‐caspr2 diseases. The pain in such cases can be treated causally.