Hemoglobin Disorders in South India. (28th June 2011)

• Record Type: Journal Article
• Authors: Chandrashekar, Vani; Soni, Mamta
• Other Names: Gibson J. S. Academic Editor.; Panizo C. Academic Editor.; Tsai A. G. Academic Editor.; White C. A. Academic Editor.
• Is Part Of: ISRN hematology. Volume 2011(2011)
• Publication Date: 2011-06-28
• Subjects: Hematology -- Periodicals; Hematologic Diseases; Hematology; Hematology; Electronic journals; Periodical; Periodicals; Fulltext; Internet Resources; Periodicals; 616.15
• DOI: 10.5402/2011/748939
• Languages: English
• ISSNs: 2090-441X

Abstract

Abstract : Cation exchange-high performance liquid chromatography (CE-HPLC) is increasingly being used as a first line of investigation for hemoglobinopathies and thalassemias. Together with a complete blood count, the CE-HPLC is effective in categorizing hemoglobinopathies as traits, homozygous disorders and compound heterozygous disorders. We carried out a one year study in Apollo Hospitals, Chennai (Tamil Nadu, South India) during which 543 abnormal chromatogram patterns were seen. The commonest disorder we encountered was β -thalassemia trait (37.9%), followed by HbE trait (23.2%), homozygous HbE disease (18.9%), HbS trait (5.3%), HbE β -thalassemia (4.6%), HbS β -thalassemia (2.5%), β -thalassemia major (2.3%), HbH (1.6%), homozygous HbS (1.4%), HbD trait (0.7%). The average value of HbA2 in β -thalassemia minor was 5.4%. β -thalassemia major had an average HbF of 88% and in HbH the mean A2 was 1.4%. Among the HbE disorders the HbA2 + HbE was 30.1% in the heterozygous state, 90.8% in the homozygous state and 54.8% in HbE β -thalassemia. In the sickle cell disorders, HbS varied from 30.9% in the trait to 79.9% in the homozygous state to 65.6% in HbS β -thalassemia.