Multifunctional Artificial Artery from Direct 3D Printing with Built‐In Ferroelectricity and Tissue‐Matching Modulus for Real‐Time Sensing and Occlusion Monitoring. (21st July 2020)

• Record Type: Journal Article
• Authors: Li, Jun; Long, Yin; Yang, Fan; Wei, Hao; Zhang, Ziyi; Wang, Yizhan; Wang, Jingyu; Li, Cheng; Carlos, Corey; Dong, Yutao; Wu, Yongjun; Cai, Weibo; Wang, Xudong
• Is Part Of: Advanced functional materials. Volume 30:Number 39(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-07-21
• Subjects: 3D printing -- artificial artery -- ferroelectric -- functional implants -- self‐powered monitoring; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202002868
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Treating vascular grafts failure requires complex surgery procedures and is associated with high risks. A real‐time monitoring vascular system enables quick and reliable identification of complications and initiates safer treatments early. Here, an electric fieldassisted 3D printing technology is developed to fabricate in situ‐poled ferroelectric artificial arteries that offer battery‐free real‐time blood pressure sensing and occlusion monitoring capability. The functional artery architecture is made possible by the development of a ferroelectric biocomposite which can be quickly polarized during printing and reshaped into devised objects. The synergistic effect from the potassium sodium niobite particles and the polyvinylidene fluoride polymer matrix yields a superb piezoelectric performance (bulk‐scale d 33 > 12 pC N −1 ). The sinusoidal architecture brings the mechanical modulus close to the level of blood vessels. The desired piezoelectric and mechanical properties of the artificial artery provide an excellent sensitivity to pressure change (0.306 mV mmHg −1, R 2 > 0.99) within the range of human blood pressure (11.25–225.00 mmHg). The high pressure sensitivity and the ability to detect subtle vessel motion pattern change enable early detection of partial occlusion (e.g., thrombosis), allowing for preventing grafts failure. This work demonstrates a promising strategy of incorporating multifunctionality to artificial biological systems for smart healthcare systems. Abstract : An electric field‐assisted 3D printing technology is developed to fabricate in situ‐poled ferroelectric artificial arteries that offer battery‐free real‐time blood pressure sensing and occlusion monitoring capability. The 3D‐printed artery provides an excellent sensitivity to pressure change within the range of human blood pressure and it enables early detection of partial occlusion (e.g., thrombosis) to prevent grafts failure.