Propagation of BOLD Activity Reveals Task-dependent Directed Interactions Across Human Visual Cortex. (24th June 2020)

• Record Type: Journal Article
• Authors: Gravel, Nicolás; Renken, Remco J; Harvey, Ben M; Deco, Gustavo; Cornelissen, Frans W; Gilson, Matthieu
• Is Part Of: Cerebral cortex. Volume 30:Number 11(2020)
• Page Start: 5899
• Page End: 5914
• Publication Date: 2020-06-24
• Subjects: BOLD activity propagation -- functional neuroanatomy -- network connectivity modeling -- resting state -- visual cortical maps; Cerebral cortex -- Periodicals; Brain -- Periodicals; 612.825
• DOI: 10.1093/cercor/bhaa165
• Languages: English
• ISSNs: 1047-3211

Abstract

Abstract: It has recently been shown that large-scale propagation of blood-oxygen-level-dependent (BOLD) activity is constrained by anatomical connections and reflects transitions between behavioral states. It remains to be seen, however, if the propagation of BOLD activity can also relate to the brain's anatomical structure at a more local scale. Here, we hypothesized that BOLD propagation reflects structured neuronal activity across early visual field maps. To explore this hypothesis, we characterize the propagation of BOLD activity across V1, V2, and V3 using a modeling approach that aims to disentangle the contributions of local activity and directed interactions in shaping BOLD propagation. It does so by estimating the effective connectivity (EC) and the excitability of a noise-diffusion network to reproduce the spatiotemporal covariance structure of the data. We apply our approach to 7T fMRI recordings acquired during resting state (RS) and visual field mapping (VFM). Our results reveal different EC interactions and changes in cortical excitability in RS and VFM, and point to a reconfiguration of feedforward and feedback interactions across the visual system. We conclude that the propagation of BOLD activity has functional relevance, as it reveals directed interactions and changes in cortical excitability in a task-dependent manner.