Siderophore piracy enhances Vibrio cholerae environmental survival and pathogenesis. Issue 11 (19th December 2020)

• Record Type: Journal Article
• Authors: Byun, Hyuntae; Jung, I-Ji; Chen, Jiandong; Larios Valencia, Jessie; Zhu, Jay
• Is Part Of: Microbiology. Volume 166:Issue 11(2020)
• Page Start: 1038
• Page End: 1046
• Publication Date: 2020-12-19
• Subjects: Anabaena variabilis -- colonization -- Cunninghamella elegans -- enterobactin -- Escherichia coli -- iron -- Vibrio cholerae -- Vibrio fluvialis; Microbiology -- Periodicals; 579
• DOI: 10.1099/mic.0.000975
• Languages: English
• ISSNs: 1350-0872

Abstract

Abstract : Vibrio cholerae, the aetiological agent of cholera, possesses multiple iron acquisition systems, including those for the transport of siderophores. How these systems benefit V. cholerae in low-iron, polymicrobial communities in environmental settings or during infection remains poorly understood. Here, we demonstrate that in iron-limiting conditions, co-culture of V. cholerae with a number of individual siderophore-producing microbes significantly promoted V. cholerae growth in vitro . We further show that in the host environment with low iron, V. cholerae colonizes better in adult mice in the presence of the siderophore-producing commensal Escherichia coli . Taken together, our results suggest that in aquatic reservoirs or during infection, V. cholerae may overcome environmental and host iron restriction by hijacking siderophores from other microbes.