Levodopa-responsive progressive encephalomyelitis with rigidity and myoclonus associated with glycine receptor antibodies. (January 2021)

• Record Type: Journal Article
• Authors: Sturchio, Andrea; Gastaldi, Matteo; Cariddi, Lucia Princiotta; Biacchi, Daniela; Espay, Alberto J.; Franciotta, Diego; Versino, Maurizio; Mauri, Marco
• Is Part Of: Parkinsonism & related disorders. Volume 82(2021)
• Page Start: 7
• Page End: 9
• Publication Date: 2021-01
• Subjects: PERM syndrome -- Autoimmune encephalitis -- Pathogenesis; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2020.11.008
• Languages: English
• ISSNs: 1353-8020

Abstract

Highlights: New dopa-responsive phenotype expands the spectrum of GlyR antibody-associated PERM syndrome. Appendicular rigidity with axial hypotonia and oculomotor abnormalities suggested hypodopaminergic tone. Downstream effects GlyR antibody may interfere with the dopamine network.