Front Cover: Cyclotide Structures Revealed by NMR, with a Little Help from X‐ray Crystallography (ChemBioChem 24/2020). (27th November 2020)

• Record Type: Journal Article
• Authors: Handley, Thomas N. G.; Wang, Conan K.; Harvey, Peta J.; Lawrence, Nicole; Craik, David J.
• Is Part Of: Chembiochem. Volume 21:Number 24(2020)
• Page Start: 3449
• Page End: 3449
• Publication Date: 2020-11-27
• Subjects: cis-proline -- cyclotides -- cystine knot -- disulfide connectivity -- NMR spectroscopy -- racemic crystallography.; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.202000778
• Languages: English
• ISSNs: 1439-4227

Abstract

Abstract : Cyclotides are a fascinating class of macrocyclic plant peptides that contain a cyclic cystine knot, a compact and highly stable structural motif. This review by D. J. Craik and co‐authors is an historical overview of the developments in NMR spectroscopy, as well as X‐ray crystallography, that have enabled the resolution of cyclotide structures and conclusive determination of disulfide connectivities of several exemplar cyclotides. Such work has been inspired by the innovative and pioneering studies of Professor Horst Kessler in cyclic peptide chemistry and NMR spectroscopy. Cover art by P.J.H.