Dopamine D4 receptor modulates inhibitory transmission in pallido‐pallidal terminals and regulates motor behavior. (8th November 2020)

• Record Type: Journal Article
• Authors: Conde Rojas, Israel; Acosta‐García, Jackeline; Caballero‐Florán, Rene Nahum; Jijón‐Lorenzo, Rafael; Recillas‐Morales, Sergio; Avalos‐Fuentes, José Arturo; Paz‐Bermúdez, Francisco; Leyva‐Gómez, Gerardo; Cortés, Hernán; Florán, Benjamín
• Other Names: Johnston Patrick guestEditor.; Pegna Alan guestEditor.; Puce Aina guestEditor.; Scott Lisa guestEditor.
• Is Part Of: European journal of neuroscience. Volume 52:Number 11(2020)
• Page Start: 4563
• Page End: 4585
• Publication Date: 2020-11-08
• Subjects: dopamine -- GABA release -- Globus pallidus -- turning behavior; Nervous system -- Periodicals; 612.8
• DOI: 10.1111/ejn.15020
• Languages: English
• ISSNs: 0953-816X

Abstract

Abstract: Two major groups of terminals release GABA within the Globus pallidus; one group is constituted by projections from striatal neurons, while endings of the intranuclear collaterals form the other one. Each neurons' population expresses different subtypes of dopamine D2‐like receptors: D2 R subtype is expressed by encephalin‐positive MSNs, while pallidal neurons express the D4 R subtype. The D2 R modulates the firing rate of striatal neurons and GABA release at their projection areas, while the D4 R regulates Globus pallidus neurons excitability and GABA release at their projection areas. However, it is unknown if these receptors control GABA release at pallido‐pallidal collaterals and regulate motor behavior. Here, we present neurochemical evidence of protein content and binding of D4 R in pallidal synaptosomes, control of [ 3 H] GABA release in pallidal slices of rat, electrophysiological evidence of the presence of D4 R on pallidal recurrent collaterals in mouse slices, and turning behavior induced by D4 R antagonist microinjected in amphetamine challenged rats. As in projection areas of pallidal neurons, GABAergic transmission in pallido‐pallidal recurrent synapses is under modulation of D4 R, while the D2 R subtype, as known, modulates striato‐pallidal projections. Also, as in projection areas, D4 R contributes to control the motor activity differently than D2 R. This study could help to understand the organization of intra‐pallidal circuitry. Abstract : GABA input to the GP via striato‐pallidal projections is modulated by D2 R while input via recurrent intra‐nuclear collaterals is modulated by D4 R.