DAA treatment failures in a low-resource setting with a high burden of hepatitis C infections: a case series. Issue 5 (23rd May 2022)

• Record Type: Journal Article
• Authors: Zahid, Hassaan; Aslam, Khawar; Dahl, Elin Hoffmann; Abbassi, Waqas; Adan, Suleiman; Van den Bergh, Rafael; Balinska, Marta A; Luck, Nasir Hassan
• Is Part Of: Oxford medical case reports. Volume 2022:Issue 5(2022)
• Publication Date: 2022-05-23
• Subjects: Clinical medicine -- Case studies -- Periodicals; 616.09
• DOI: 10.1093/omcr/omac049
• Languages: English
• ISSNs: 2053-8855

Abstract

ABSTRACT: Globally, 58 million people are living with hepatitis C virus (HCV) infection and 1.5 million new patients are infected every year. The advent of direct acting antivirals (DAAs) has revolutionized the treatment of HCV, opening the door to the ambitious World Health Organization HCV infection elimination strategy by 2030. However, emerging resistance to DAAs could jeopardize any hope of achieving these targets. We discuss a series of 18 patients within a resource-limited setting, who after failing standard sofosbuvir-daclatasvir-based regimen also failed to respond to advanced pan-genotypic treatment regimens, i.e. sofosbuvir-velpatasvir, sofosbuvir-velpatasvir-ribavirin and sofosbuvir-velpatasvir-voxilaprevir. To avoid the spread of refractory HCV strains within the existing epidemic, we call for increased attention and research regarding patients failing treatment on standard pan-genotypic regimens and the spread of HCV-resistant strains within the communities.