The effect of vitamin D supplementation on glycemic status of elderly people with prediabetes: a 12-month open-label, randomized-controlled study. Issue 1 (2nd January 2022)

• Record Type: Journal Article
• Authors: Zaromytidou, Evangelia; Koufakis, Theocharis; Dimakopoulos, Georgios; Drivakou, Despina; Konstantinidou, Stavroula; Antonopoulou, Vasiliki; Grammatiki, Maria; Manthou, Eleni; Iakovou, Ioannis; Gotzamani-Psarrakou, Anna; Kotsa, Kalliopi
• Is Part Of: Expert review of clinical pharmacology. Volume 15:Issue 1(2022)
• Page Start: 89
• Page End: 97
• Publication Date: 2022-01-02
• Subjects: Prediabetes -- vitamin D -- older adults -- insulin resistance; Clinical pharmacology -- Periodicals; 615.105
• DOI: 10.1080/17512433.2022.2043153
• Languages: English
• ISSNs: 1751-2433

Abstract

ABSTRACT: Background: Data on the efficacy of vitamin D in improving the glycemic status of elderly people with prediabetes are scarce. This open-label, randomized-controlled trial investigated the effect of vitamin D supplementation on glycemic markers of Greek people with prediabetes aged 60 years or above, over 12 months. Research design and methods: Participants were randomized to a weekly vitamin D3 dose of 25, 000 IU (n = 45) or nothing (n = 45), on top of lifestyle measures. Anthropometric and glycemic markers were assessed at baseline, 3, 6, and 12 months Results: Supplemented participants demonstrated a significant increase in 25(OH)D concentrations at 3, 6, and 12 months compared to baseline . In the intervention group, fasting glucose was decreased at 6 months compared to baseline (96.12 ± 5.51 vs 103.40 ± 12.05 mg/dl, p < 0.01) and glycated hemoglobin was significantly lower at 6 and 12 months compared to baseline [5.82 ± 0.21% vs 5.87 ± 0.21%, p = 0.004 and 5.80 ± 0.23% vs 5.87 ± 0.21%, p < 0.001, respectively]. Conclusions: Vitamin D could be complementary to lifestyle change strategy for the management of prediabetes in the elderly. Clinical trial registration: ISRCTN51643592.