Excessive Subchorionic Fibrinoid Deposition as a Component of Massive Perivillous Fibrin Deposition: A Case With Maternal Immune Thrombocytopenia. (July 2022)

• Record Type: Journal Article
• Authors: Taweevisit, Mana; Nimitpanya, Panachai; Thorner, Paul S.
• Is Part Of: Pediatric and developmental pathology. Volume 25:Number 4(2022)
• Page Start: 466
• Page End: 469
• Publication Date: 2022-07
• Subjects: placenta -- massive perivillous fibrin deposition -- maternal floor infarction -- subchorionic region -- immune thrombocytopenia; Pediatric pathology -- Periodicals; Children -- Diseases -- Periodicals; Diagnosis, Laboratory -- Periodicals; Abnormalities, Human -- Periodicals; Child development -- Periodicals; Pediatrics -- Periodicals; 616.07
• DOI: 10.1177/10935266211069331
• Languages: English
• ISSNs: 1093-5266

Abstract

Maternal floor infarction (MFI) and massive perivillous fibrin deposition (MPFD) are overlapping placental disorders of unknown etiology, associated with adverse obstetric outcome, and a significant risk of recurrence. We describe a 31-year-old mother with asymptomatic thrombocytopenia throughout pregnancy and a positive lupus anticoagulant. She delivered a normal female neonate at term, whose weight was small for gestational age, with a placenta weighing less than the 10 th percentile. Placental examination showed MPFD together with excessive subchorionic fibrinoid deposition. The placenta showed diffuse C4d deposition and an immune-mediated reaction was postulated for the pathogenesis of the placental changes. We suggest that excessive subchorionic fibrinoid deposition may be part of the morphologic spectrum of MFI/MPFD.