5-HTTLPR Polymorphism Modulates Neural Mechanisms of Negative Self-Reflection. (15th April 2013)
- Record Type:
- Journal Article
- Title:
- 5-HTTLPR Polymorphism Modulates Neural Mechanisms of Negative Self-Reflection. (15th April 2013)
- Main Title:
- 5-HTTLPR Polymorphism Modulates Neural Mechanisms of Negative Self-Reflection
- Authors:
- Ma, Yina
Li, Bingfeng
Wang, Chenbo
Shi, Zhenhao
Sun, Yun
Sheng, Feng
Zhang, Yifan
Zhang, Wenxia
Rao, Yi
Han, Shihui - Abstract:
- Abstract : Cognitive distortion in depression is characterized by enhanced negative thoughts about both environment and oneself. Carriers of a risk allele for depression, that is, the short (s) allele of the serotonin transporter promoter polymorphism (5-HTTLPR), exhibit amygdala hyperresponsiveness to negative environmental stimuli relative to homozygous long variant (l/l). However, the neural correlates of negative self-schema in s allele carriers remain unknown. Using functional MRI, we scanned individuals with s/s or l/l genotype of the 5-HTTLPR during reflection on their own personality traits or a friend's personality traits. We found that relative to l/l carriers, s/s carriers showed stronger distressed feelings and greater activity in the dorsal anterior cingulate (dACC)/dorsal medial prefrontal cortex (dmPFC) and the right anterior insula (AI) during negative self-reflection. The 5-HTTLPR effect on the distressed feelings was mediated by the AI/inferior frontal (IF) activity during negative self-reflection. The dACC/dmPFC activity explained 20% of the variation in harm-avoidance tendency in s/s but not l/l carriers. The genotype effects on distress and brain activity were not observed during reflection on a friend's negative traits. Our findings reveal that 5-HTTLPR polymorphism modulates distressed feelings and brain activities associated with negative self-schema and suggest a potential neurogenetic susceptibility mechanism for depression.
- Is Part Of:
- Cerebral cortex. Volume 24:Number 9(2014:Sep.)
- Journal:
- Cerebral cortex
- Issue:
- Volume 24:Number 9(2014:Sep.)
- Issue Display:
- Volume 24, Issue 9 (2014)
- Year:
- 2014
- Volume:
- 24
- Issue:
- 9
- Issue Sort Value:
- 2014-0024-0009-0000
- Page Start:
- 2421
- Page End:
- 2429
- Publication Date:
- 2013-04-15
- Subjects:
- 5-HTTLPR -- anterior cingulate -- anterior insula -- FMRI -- negative self-schema
Cerebral cortex -- Periodicals
Brain -- Periodicals
612.825 - Journal URLs:
- http://cercor.oupjournals.org ↗
http://cercor.oxfordjournals.org ↗
http://www.ncbi.nlm.nih.gov/pmc/?term=%22Cereb ↗
http://ukcatalogue.oup.com/ ↗
http://firstsearch.oclc.org ↗ - DOI:
- 10.1093/cercor/bht099 ↗
- Languages:
- English
- ISSNs:
- 1047-3211
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3120.027550
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