Anxiety and Performance: The Disparate Roles of Prefrontal Subregions Under Maintained Psychological Stress. (20th February 2013)

• Record Type: Journal Article
• Authors: Takizawa, Ryu; Nishimura, Yukika; Yamasue, Hidenori; Kasai, Kiyoto
• Is Part Of: Cerebral cortex. Volume 24:Number 7(2014:Jul.)
• Page Start: 1858
• Page End: 1866
• Publication Date: 2013-02-20
• Subjects: anxiety -- near-infrared spectroscopy -- noninvasive monitoring -- prefrontal subregions -- psychological stress; Cerebral cortex -- Periodicals; Brain -- Periodicals; 612.825
• DOI: 10.1093/cercor/bht036
• Languages: English
• ISSNs: 1047-3211

Abstract

Abstract : Despite increasing interest in anxiety and psychological stress in daily life, little is known about neural correlates that underlie maintained psychological stress and their relationship with anxiety. In particular, the activation characteristics of lateral prefrontal subregions and their relationship with anxiety and cognitive performance under maintained psychological stress remain unknown. This study used near-infrared spectroscopy (NIRS), a noninvasive and "real-world" functional neuroimaging method, to investigate the hemodynamic responses in wide areas of the prefrontal cortex (PFC) and the influence of anxiety under conditions of maintained stress induced by a continuous arithmetic task (2 sets, 15 min each) performed in a natural sitting posture. Although anxiety and performance are not directly correlated, the hemodynamic response in the medial portion of the lateral PFC (dorsolateral and frontopolar PFC) was significantly associated with anxiety, while hemodynamic responses in the ventrolateral PFC were associated with performance. Additionally, in the same medial region of the lateral PFC, trait and state anxieties were related to changes in deoxy- and oxy-hemoglobin concentrations, respectively. This NIRS finding suggests disparate roles for prefrontal subregions in anxiety and performance under psychological stress and may lead to a better understanding of neural correlates for anxiety in everyday life.