The impact of cancer treatment on quality of life in patients with pancreatic and periampullary cancer: a propensity score matched analysis. Issue 4 (April 2022)

• Record Type: Journal Article
• Authors: Mackay, Tara M.; Dijksterhuis, Willemieke P.M.; Latenstein, Anouk E.J.; van der Geest, Lydia G.; Sprangers, Mirjam A.G.; van Eijck, Casper H.J.; Homs, Marjolein Y.V.; Luelmo, Saskia A.C.; Molenaar, I. Quintus; van Santvoort, Hjalmar; Schreinemakers, Jennifer M.J.; Wilmink, Johanna W.; Besselink, Marc G.; van Laarhoven, Hanneke W.; van Oijen, Martijn G.H.
• Is Part Of: HPB. Volume 24:Issue 4(2022)
• Page Start: 443
• Page End: 451
• Publication Date: 2022-04
• Subjects: Liver -- Diseases -- Periodicals; Biliary tract -- Diseases -- Periodicals; Pancreas -- Diseases -- Periodicals; 616.362005
• DOI: 10.1016/j.hpb.2021.09.003
• Languages: English
• ISSNs: 1365-182X

Abstract

Abstract: Background: The impact of pancreatic and periampullary cancer treatment on health-related quality of life (HRQoL) is unclear. Methods: This study merged data from the Netherlands Cancer Registry with EORTC QLQ-C30 and -PAN26 questionnaires at baseline and three-months follow-up of pancreatic and periampullary cancer patients (2015–2018). Propensity score matching (1:3) of group without to group with treatment was performed. Linear mixed model regression analyses were performed to investigate the association between cancer treatment and HRQoL at follow-up. Results: After matching, 247 of 629 available patients remained (68 (27.5%) no treatment, 179 (72.5%) treatment). Treatment consisted of resection (n = 68 (27.5%)), chemotherapy only (n = 111 (44.9%)), or both (n = 40 (16.2%)). At follow-up, cancer treatment was associated with better global health status (Beta-coefficient 4.8, 95% confidence-interval 0.0–9.5) and less constipation (Beta-coefficient −7.6, 95% confidence-interval −13.8–1.4) compared to no cancer treatment. Median overall survival was longer for the cancer treatment group compared to the no treatment group (15.4 vs. 6.2 months, p < 0.001). Conclusion: Patients undergoing treatment for pancreatic and periampullary cancer reported slight improvement in global HRQoL and less constipation at three months-follow up compared to patients without cancer treatment, while overall survival was also improved.